Changes in peripheral blood double-negative T-lymphocyte (CD3+ CD4− CD8−) populations associated with acute cellular rejection after liver transplantation

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Peripheral blood lymphocyte phenotype can predict rejection episodes after orthotopic liver transplantation.

IT IS WIDELY known that, unlike other transplants, liver allografts behave as an immunologically favored organ and that their outcome is apparently independent of HLA compatibility, showing a special tolerance status and prolonged survival. It is also known that controling rejection is the most important aspect in the treatment of posttransplant recipients because it determines prognosis. Chang...

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Low Double-Negative CD3+CD4−CD8− T Cells Are Associated with Incomplete Restoration of CD4+ T Cells and Higher Immune Activation in HIV-1 Immunological Non-Responders

Failure of immune reconstitution increases the risk of AIDS or non-AIDS related morbidity and mortality in HIV-1-infected patients. CD3+CD4-CD8- T cells, which are usually described as double-negative (DN) T cells, display CD4-like helper and immunoregulatory functions. Here, we have measured the percentage of DN T cells in the immune reconstituted vs. non-immune reconstituted HIV-1-infected in...

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Peripheral Blood Lymphocyte Subsets (CD4+, CD8+ T Cells, NK Cells) in Patients with Cardiovascular and Neurological Complications after Carotid Endarterectomy

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Interleukin-28B rs12979860 C/T Polymorphism and Acute Cellular Rejection after Liver Transplantation

BACKGROUND Interleukin-28 (IL-28B) rs12979860 C/T polymorphism is a known predictor of sustained virological response after antiviral treatment in hepatitis C. IL-28B affects the innate immune system as well as intrahepatic expression level of interferon-stimulated genes. OBJECTIVE To investigate the effect of recipient IL-28B polymorphism on occurrence of acute rejection after liver transpla...

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ژورنال

عنوان ژورنال: Liver Transplantation and Surgery

سال: 1998

ISSN: 1074-3022

DOI: 10.1002/lt.500040207